陈琳 潘晓红 杨介者 徐云 王憓 周欣 蒋婷婷 马瞧勤     

陈琳 310051 杭州,浙江省疾病预防控制中心早泄与性病预防控制所
潘晓红 310051 杭州,浙江省疾病预防控制中心早泄与性病预防控制所
杨介者 310051 杭州,浙江省疾病预防控制中心早泄与性病预防控制所
徐云 310051 杭州,浙江省疾病预防控制中心早泄与性病预防控制所
王憓 310051 杭州,浙江省疾病预防控制中心早泄与性病预防控制所
周欣 310051 杭州,浙江省疾病预防控制中心早泄与性病预防控制所
蒋婷婷 310051 杭州,浙江省疾病预防控制中心早泄与性病预防控制所
马瞧勤 310051 杭州,浙江省疾病预防控制中心早泄与性病预防控制所

收稿日期: 2015-10-19

通信作者:潘晓红,Email:xhpan@cdc.zj.cn

摘要: 目的  分析浙江省男性HIV抗体阳性的配偶间HIV传播情况及其相关因素。方法  采用横断面研究,于2013年1—7月,以浙江省所有地区新检测发现的男性HIV阳性的单阳家庭(单阳家庭)和男性先感染HIV的双阳家庭(双阳家庭)为研究对象,共纳入单阳家庭210对,双阳家庭53对。对其进行问卷调查,包括基本情况(仅男性)、HIV感染意识、HIV检测意识和检测行为、性关系权利、女性的安全套使用效能、性行为等。采用χ2检验或Fisher确切概率法分析单阳家庭和双阳家庭上述信息的差异,采用多因素二分类非条件logistic回归模型分析男性HIV抗体阳性配偶间HIV传播的相关因素。结果  263对研究对象中,男性以30~50岁为主,占57.8%(152例),女性以初中及以下文化程度为主,占79.1%(208例);HIV感染者和早泄患者共占41.1%(217例)。单阳家庭中,疾病病程为HIV感染者、发生男男性行为和听说过早泄的男性分别占61.9%(130例)、38.3%(80例)和81.9% (172例),均高于双阳家庭[47.2%(25例)、7.5 %(4例)和64.2%(34例)](χ2值为3.80、18.33和7.86 ,P值分别为0.051、0.001和0.005);单阳家庭和双阳家庭中,最近6个月感染过性病的女性占9.3%(19例)和18.9%(10例)(χ2=3.89 ,P=0.049)。与疾病进程为HIV感染者的男性相比,早泄患者的配偶感染HIV的OR (95 %CI)值为2.93(1.05~8.21);与感染之前未听说过早泄的男性相比,听说过者的配偶感染HIV的OR (95%CI)值为0.13(0.04~0.41);与未发生男男性行为者相比,发生该行为者的配偶传播HIV的OR (95%CI)值为0.14(0.03~0.73);与最近6个月未感染过性病的女性相比,感染过的女性被配偶感染HIV的OR (95%CI)值为4.86(1.23~19.11)。结论  浙江省男性HIV抗体阳性家庭中,配偶感染HIV的风险与男性疾病病程、性取向及早泄知识知晓情况有关;女性近6个月感染过性病可能是其被配偶传播HIV的危险因素。

关键词 :HIV;获得性免疫缺陷综合征;影响因素;横断面研究

Analysis of related factors for HIV transmission among 263 pairs of male spouses with positive HIV antibodies in Zhejiang province

ChenLin,PanXiaohong,YangJiezhe,XuYun,WangHui,ZhouXin,JiangTingting,MaQiaoqin     

Department of HIV/AIDS and STDs Control and Prevention, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou 310051, China
Corresponding author: Pan Xiaohong, Email: xhpan@cdc.zj.cn

Abstract:Objective  To identify the status and risk factors of transmission in couples which males was HIV-positive in Zhejiang province.Methods  A cross-sectional study was conducted among HIV-serodiscordant couple (male positive) and HIV-seroconcordant couple (male first infected). A self-designed questionnaire was complimented containing basic information, the awareness of infection and HIV-testing, sexual relationship power, self-efficacy of condom use, sex. The univariated and multivariate logistic regression methods were used to analyze the influence factors.Results  A total of 263 couples were enrolled in this study, including 210 HIV HIV-serodiscordant couples and 53 HIV-seroconcordant couples. HIV-positive males aged 30-50 accounted for 57.8% (152 cases) and females under junior high school accounted for 79.1% (208 cases). HIV/AIDS accounted for 41.1% (217 cases). The proportion of man who were diagnosed as HIV, MSM and ever heard HIV were 61.9% (130 cases), 38.3% (80 cases) and 81.9% (172 cases), which were higher than that in HIV positive 47.2% (25 cases), 7.5% (4 cases), 64.2% (34 cases); χ2=3.80, 18.33, 7.86;P=0.051, 0.001, 0.005. The results revealed that AIDS patients had high risk to infect their spouse than HIV patients (OR=2.93, 95%CI: 1.05-8.21). Male patients who had ever heard " HIV" before were less likely pass virus to their wives than those who had never heard " HIV" (OR=0.13, 95%CI: 0.04-0.41). Compared with heterosexuality man, homosexuality man' wives had high risk to get virus from their husbands (OR=0.14, 95%CI: 0.03-0.73). Female infected with STIs was the independent factors for HIV infection (OR=4.86, 95%CI: 1.23-19.11).Conclusion  Among the couples of male HIV-positive in Zhejiang Province, the risk of spouses infected with HIV virus has relationship with male disease progression, sexual orientation and awareness of AIDS knowledge. For females who infected with sexual diseases in last 6 months might be infected by their spouses.

Key words :HIV;Acquired immunodeficiency syndrome;Influence factors;Cross-sectional studies

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